What is Chlorhexidine digluconate?
发布时间：2016-05-16
Reference to Wikipedia, Chlorhexidine digluconate is an antibacterial used as an antiseptic and for other applications. It is a cationic polybiguanide (bisbiguanide). It is used primarily as its salts (e.g., the dihydrochloride, diacetate, and digluconate). It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. It is used in disinfectants (disinfection of the skin and hands), cosmetics (additive to creams, toothpaste, deodorants, and antiperspirants), and pharmaceutical products (preservative in eye drops, active substance in wound dressings and antiseptic mouthwashes).
Chlorhexidine digluconate's adverse reactions:
1. May cause contact dermatitis. High concentration solution ocular conjunctiva strong irritant.
2. It can be used to make oral surface coloring, who as early as 1 week after use occurs. Use after 6 months to about 50% of patients can be stained teeth, about 10% of patients with severe coloring, more dental plaque deposits were colored more pronounced. Dentures due to surface or rough edges can occur permanently colored.
3. Taste changes can occur, continue treatment recoverable.
4.10 to 18-year-old children and adolescents may occur Oral painless superficial desquamation.
5. Rare local irritation and allergic reactions.
6. Children after accidental ingestion of this product, there may be symptoms of alcoholism (such as slurred speech, drowsiness, gait, shaking, etc.), should be sent to emergency treatment immediately.
At physiologic pH, Chlorhexidine digluconate dissociate and release the positively charged chlorhexidine cation. The bactericidal effect is a result of the binding of this cationic molecule to negatively charged bacterial cell walls. At low concentrations of chlorhexidine, this results in a bacteriostatic effect; at high concentrations, membrane disruption results in cell death.
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