Chlorhexidine digluconate is often used as an active ingredient in mouthwash designed to reduce dental plaque and oral bacteria. It has been shown to have an immediate bactericidal action and a prolonged bacteriostatic action due to adsorption onto the pellicle-coated enamel surface. If it is not deactivated, chlorhexidine lasts longer in the mouth than other mouthwashes, which is partly why it is to be preferred over other treatments for gingivitis. To treat periodontal pockets equal or greater than 5 mm, chlorhexidine is also available in high concentration (36%) in a gelatin chip.
There are oral pathologic conditions in which the maintenance of oral hygiene with the twice-daily use with 0.12% Chlorhexidine digluconate solution (in which a salt of chlorhexidine and gluconic acid has been dissolved) is required for healing and regeneration of the oral tissues. These conditions included gingivitis, periodontitis, dental traumas (such as subluxation), oral cysts, and after wisdom tooth extraction. The clinical efficacy of the application of chlorhexidine as a component of oral rinses is well documented by many clinical studies summarized by review articles.
Precautions of Chlorhexidine digluconate:
1. This product can not swallow.
2. Avoid contact with eyes and high concentration solution other sensitive organizations; avoid using this product for bladder lavage.
3. This product is not placing containers with cork, so this product inactivation.
4. This product is decomposed by heat treatment for a long time, so the higher the concentration of the solution (1%) can not be autoclaved; shall not exceed 115 ℃ when the dilute solution (0.1%) autoclaving for 30 minutes.
5. This product with soap, potassium iodide, etc. incompatibility. 0.05% concentration of the product with borax, bicarbonate, carbonate, oxide, citrate, phosphate and sulfate incompatibility, because of the low solubility of the salts may be formed after 24 hours to settle.