Chlorhexidine digluconate is superior to other disinfectants and has few side-effects. It is widely used in the hospital setting to disinfect skin and mucous membranes. Outside the hospital setting, chlorhexidine is also widely used, for example by dentists, in cosmetic products as a preservative, and in products sold over the counter in pharmacies.
The prevalence of Chlorhexidine digluconate contact allergy does not seem to be higher in Denmark than in other European countries. Patch testing with both chlorhexidine diacetate and Chlorhexidine digluconate may be beneficial. Testing for immediate-type allergy in patients with a positive patch test reaction to chlorhexidine is recommended. Chlorhexidine-containing products used in the healthcare setting and in cosmetics are potential causes of sensitization and allergy. Re-exposure is common, highlighting the fact that patients and healthcare personnel need to be well informed about possible sources of exposure.
Objective: to establish HPLC Chlorhexidine digluconate metronidazole lotion metronidazole and compound chlorhexidine gluconate and chlorhexidine gargle content determination method using Waters C18 column using methanol - water - triethylamine ( 56:44:0.1, with 50% phosphoric acid adjusted to pH 3.0) as the mobile phase, detection wavelength 295 nm. the results of the two components can be well separated, metronidazole and chlorhexidine acetate linear range of 10 ~ 29 μg * mL-1 (r = 0.999 9) and 41 ~ 124 μg * mL-1 (r = 0.999 8); the average recoveries were 99.6% and 99.5%, RSD were less than 0.9% Conclusion the method is simple, accurate and reliable. For compound preparation of two components simultaneously.