Study population: This was a retrospective study of all patients patch tested with Chlorhexidine digluconate at the Department of Dermato-Allergology at Copenhagen University Hospital Gentofte during an 11-year-period: 1 January 2003 to 31 December 2013 (n = 8497). Chlorhexidine diacetate and chlorhexidine digluconate were routinely applied as a supplement to the baseline series for the entire period: from 1 January 2003 to 1 September 2008 in concentrations of 1.0% aq., and from 1 September 2008 to 31 December 2013 in concentrations of 0.5% aq. The chlorhexidine test substances were prepared in the department from 2003 to 1 September 2008; from 1 September 2008 to 15 March 2009, test substances from Chemotechnique were used; from 15 March 2009 until 31 December 2013, chlorhexidine diacetate 0.5% aq. from Chemotechnique (Vellinge, Sweden) and chlorhexidine digluconate 0.5% aq. from Trolab (Barsbüttel, Germany) were used. Patient data were collected from the clinical database of contact allergy hosted in the department. Information available from the database included age, MOAHLFA index (Male, Occupation, Atopic dermatitis, Leg dermatitis, Hand dermatitis, Facial dermatitis, and Age > 40 years), and patch test results.
Patch testing for Chlorhexidine digluconate: Eight-millimetre Finn Chambers® were used, and patch tests were applied to the upper back. The occlusion time was 48 h, and reading was performed at day (D)2, D3, and D5/D7, in accordance with ICDRG recommendations. Reactions scored as 1+, 2+ and 3+ were interpreted as positive. Irritant reactions and doubtful reactions were interpreted as negative. In cases of retesting, patch test data obtained at the first visit were used in the analysis. In cases of the same patch test severity on more than one reading, the day of the first reading was used in the analysis.
Toxic erythema newborn child is the most common skin disease in neonates Sri Lanka, the disease known as neonatal allergic erythema, or neonatal urticaria. Our department in January 2007 ~ December 2008 application Chlorhexidine digluconate treatment of neonatal toxic erythema 856 cases, now clinical observations reported below. 1 Clinical data 1.1 General Information The group of children with 856 cases, 425 cases were male, female 431 cases, an average disease within 7d.