There was a significantly higher rate of irritant reactions when testing was performed with 1.0% chlorhexidine diacetate than when it was performed with 1.0% chlorhexidine digluconate [5.1% (n = 199) and 2.1% (n = 80), respectively, p < 0.001]. In contrast, there was no statistically significance difference in the rate of irritant reactions when testing was performed with 0.5% chlorhexidine diacetate and when it was performed with 0.5% chlorhexidine digluconate [0.5% (n = 24) and 0.3% (n = 15), respectively, p = 0.14]. Overall, there was a significantly higher rate of irritant reactions in the group tested with 1.0% chlorhexidine diacetate and 1.0% chlorhexidine digluconate than in the group tested with 0.5% chlorhexidine diacetate and 0.5% chlorhexidine digluconate [3.6% (n = 279) and 0.4% (n = 39), respectively, p < 0.001].
Of the 82 patients with a positive patch test reaction to chlorhexidine, 29 were prick tested with chlorhexidine digluconate, and 3 were positive. Of the 3 patients, 1 had a strongly positive (2+) patch test reaction to 1.0% chlorhexidine digluconate and an extremely positive (3+) patch test reaction to 1.0% chlorhexidine diacetate; the 2 remaining patients had strongly positive (2+) patch test reactions to 1.0% and 0.5% chlorhexidine diacetate, respectively.
Objective: To study the Chlorhexidine digluconate to inhibit the growth of cariogenic bacteria and anti-plaque formation effect. Methods: simulating human oral environment and several artificial plaque cariogenic bacteria mixed model, chlorhexidine gluconate mouthrinse suppress cariogenic bacteria and anti-plaque formation and scanning electron microscopy were isotopically labeled bacterial count testing. Result: isotope count display using chlorhexidine gluconate mouthrinse significantly reduced the number of bacteria, SEM prove chlorhexidine gluconate mouthwash to prevent the formation of bacterial plaque accumulation. Conclusion: chlorhexidine gluconate mouthwash have a significant influence on inhibiting the growth of cariogenic bacteria, anti-plaque formation.