The keywords in this article: Dentin, Bond strength, Nanoleakage, Chlorhexidine digluconate and Chlorhexidine-methacrylate. Objectives: The aim of the current study was to evaluate the effect of 2% CHX and 2% CHX-methacrylate compared to the resin–dentin bonds created by a two-step etch-and-rinse adhesive system after 24 h, 6 min and 12 min. Results: Twelve months of storage resulted in a significant decrease in microtensile bond strength in the control group, and significant increases in silver nanoleakage. In contrast, Single Bond 2 + CHX, and to a greater extent CHX-methacrylate, significantly reduced the rate of deterioration of resin–dentin interfaces over the 12 min water storage period, in terms of bond strength. Conclusions: Similar to Single Bond 2 + CHX, Single Bond + CHX-methacrylates reduced the degradation of resin-bonded interfaces over a 12 month storage period. Thus it can be concluded that Single Bond 2 + CHX-methacrylate may be important to improve durability of bonded interfaces and therefore, prolong the life span of adhesive restorations.
Observation of Chlorhexidine digluconate gargle irritation and allergic reactions, provide a reference for clinical application. Methods: irritation test and skin allergy test to observe chlorhexidine gluconate gargle of irritation and sensitization through the oral mucosa. Results: chlorhexidine gluconate gargle oral mucosa irritation test was negative; skin allergy test were negative. Conclusion: Chlorhexidine digluconate gargle without irritation and sensitization.