The log10 bacterial reduction was assessed after topically applying 106 CFU of test microorganisms to the RHE models, which had been pretreated for 15 min with equimolar concentrations of either chlorhexidine digluconate or OCT. The results of the quantitative suspension tests for the different incubation times are represented. The inactivation mixture TSHC was effective for CHG and OCT in the presence of P. aeruginosa and TSLS inactivated both antiseptic agents in the presence of S. aureus. After 2 h of incubation, the log10 reduction was 0.3 for P. aeruginosa using OCT pretreated RHE, which was significantly different from that of the control and the CHG-RHE, which demonstrated low antimicrobial effect.
The test microorganism S. aureus was not detectable after 24 h of incubation after contact with both chlorhexidine digluconate- and OCT-RHE, which is equal to a log10 bacterial reduction of more than 5.6. After 15 min of contact, the log10 reduction was 1.2 for S. aureus utilizing CHG pretreated RHE, which was significantly different from that of 3.6 of OCT-RHE. The log10 reduction of S. aureus was scaled up to either 3.3 for CHG-RHE or 4.2 for OCT-RHE after 4 h incubation.
Learn 2% chlorhexidine digluconate skin disinfectant effect in the maintenance of central venous catheter. Methods: 157 cases of patients admitted catheter (study group) and 150 cases (control group) were compared. Result: 9 cases of infection in the control group, the study group occurred 0 cases, the difference was statistically significant (P = 0.002). Rash 16 cases in the control group, there was three study group , the difference was statistically significant (P = 0.001). Conclusion: 2% chlorhexidine gluconate skin disinfectant in central venous catheter maintenance has obvious advantages over other disinfectants.