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Advantages and Disadvantages Of Chlorhexidine digluconate

      Chlorhexidine digluconate solution, BP is mostly used as a topical disinfectant. It is also used in cosmetics as well as pharmaceutical products such as eye drops and antiseptic mouthwash for treatment of periodontal disease. Spectrum Chemical manufactured BP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.


      One of the primary advantages of chlorhexidine digluconate is the persistence of its anti-microbial properties. When used orally, chlorhexidine digluconate is absorbed into the teeth and thus provides extended protection against oral bacteria such as gingivitis. When used topically, it both kills bacteria and contact and has a lingering residual effect, preventing bacteria from regrowing on the application site.

      Potential side effects of chlorhexidine digluconate use include staining and yellowing of teeth after prolonged oral use and the potential for skin sensitivity after topical use.

      A topical anti-microbrial agent and disinfectant used to treat fungus, bacteria and other skin infections. In cosmetics, it mainly functions as a biocide, oral care agent and preservative. As a biocidal agent, it helps cleanse the skin and eliminates odor by destroying the growth of microorganisms. In addition to preventing bacterial growth on contact, it also has residual effects that inhibit microbial regrowth after application. Chlorhexidine digluconate is widely used in dentistry because of its ability to eliminate plaque formation. Its anti-bacterial properties also make it an effective preservative that protects a cosmetic formulation from contamination and spoilage.  It can be found in various personal care products such as mouthwash, hair dye, foundation, anti-aging treatment, facial moisturizer, sunscreen, eye makeup, acne treatment, exfoliant/scrub, cleanser and after shave.

      The Cosmetic Ingredient Review (CIR) Expert Panel has reviewed the safety of this ingredient, and determined it as safe to use at up to concentrations of .16%. The panel's clinical research on this ingredient demonstrated it to be non-irritating and non-carconogenic. However, this ingredient was shown to be slightly toxic in oral and inhalation studies, and some bacterial assays it tested positive for mutagenesis. Furthermore, dermal sensitization occurred when patch tests of 1% concentrations of chlorhexidine digluconate were administered on Eczema patients. The EU Cosmetics Directive permits it to be used as a cosmetic preservative at concentrations up to 0.3%.

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