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History of the Chlorhexidine from its birth

Chlorhexidine is being used for almost 60 years and has been used in more than 60 pharmaceuticals and medical devices. Its broad efficacy and safety has been proved over that period. In many instance, Chlorhexidine Base product has become the standard in patient care for the nonsocial infection and for the prevention of disease. Although its molecule has been used for a long time but still it is being used in new applications.

Chlorhexidine in the 50’s

 In 1954, an article on a new investigational antimicrobial was published by The Imperial Chemical Industries Limited (ICI). While the scientists of Imperial Chemical Industries, Manchester were busy in doing their research on synthesis of anti-malarial agents, they discovered Chlorhexidine. In the United Kingdom,Chlorhexidine Base,Chlorhexidine digluconate was first introduced commercially as a disinfectant and also as a topical antiseptic in the year 1954.

Chlorhexidine in 70’s

 In the 60’s, there was no big deal happened with Chlorhexidine. Hand washing with Chlorhexidine had reduced 86%-92% skin flora and was first introduced into the US. In the year 1976, it was first realized that Chlorhexidine could be used as an oral agent who demonstrated that its ability was to inhibit the formation and development of plaque. It was proved on that time that the antiseptic was the most effective and safest anti-plaque agent. It was indicated for use in the general people and in high risk groups of patients. This age gave the research of Chlorhexidine a smooth flow for future.

 Chlorhexidine in the 80’s

 The first urology lubricant with Chlorhexidine was cleared by FDA ( Food and Drug Administration) of United States America (US) in 1981 and in 1988, the first Chlorhexidine and alcohol skin preparation combination was launched in the United States.

Chlorhexidine in the 90’s

The first Chlorhexidine base  vascular access catheter became commercially available in 1992 and it was impregnated with Chlorhexidine and silver sulfadiazine. In 1993, the first Chlorhexidine sponge dressing was cleared by Food and Drug Administration of United States. It made the final move for Chlorhexidine. After that, it went for a big bang in the back ground of medicinal equipment.

 

Chlorhexidine in the 20’s

Chlorhexidine was added to a ventilator bundle with comprehensive oral care in 2001 and was revealed thatit was one of the most important equipment in the world of medicine. In 2005, Food and Drug Administration of United States cleared the 2% Chlorhexidine gluconate cloth for pre-operative preparation. The first Chlorhexidine-impregnated needless connectors were also cleared by the Food and Drug Administration of United States. PICC, Peripherally Inserted Central Catheter approved the first Chlorhexidine impregnated as an antimicrobial catheter in the year 2010. At the last, in 2012, The first Chlorhexidine based PICC ( Peripherally Inserted Central Catheter) was certified by the Food and Drug Administration of United States as an antithrombogenic catheter  in addition to its antimicrobial indication.

Now a day, Chlorhexidine is largely used as a most popular disinfectant in a range of healthcare products, including topical skin disinfectants, central venous catheters, and hand washing solutions, needleless IV connectors and many more.

Transferred from:https://rnlaboratories.wordpress.com/2014/03/16/history-of-the-chlorhexidine-from-its-birth/

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