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The application of N-Hydroxyphthalimide(NHPI) in pharmaceutical area
N-hydroxyphthalimide (NHPI) has a wide range of applications in the pharmaceutical field, mainly reflected in the following aspects:
  1. Cancer Drug Synthesis
    NHPI can be used to synthesize various anti-cancer drugs, such as 4H-pyran-4-carbaldehyde oxime, RNA peptide conjugates, and glycopeptide cephalosporins. These compounds can effectively inhibit the spread of cancer cells.
  2. Antiviral Drug Synthesis
    NHPI is an important intermediate in the synthesis of the antibiotic Amikacin. Amikacin is mainly used to treat severe infections caused by Enterobacter spp., Proteus spp., Escherichia coli, and other bacterial species.
  3. Diabetes Drug Synthesis
    NHPI can be used to synthesize Nateglinide, a novel oral hypoglycemic agent, which is suitable for patients with Type II diabetes who have not responded to diet, exercise, and α-glucosidase inhibitors.
  4. Immune Disease Modulating Drugs Synthesis
    NHPI can be used to synthesize thienopyrimidine-2,4(1H,3H)-dione, which is a regulator for autoimmune diseases.
  5. Other Drug Synthesis
    NHPI can also be used as an intermediate to synthesize other drugs, such as Amlodipine Besylate and Furandiamine.
The applications of NHPI in the pharmaceutical field are not limited to the synthesis of the above-mentioned drugs. Its unique chemical properties make it an important candidate in drug development, especially in the development of new drugs and high-performance materials, where its potential will gradually increase.
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