N-(2-Hydroxyethyl)phthalimide (NHPI), also known as N-(Hydroxyethyl)phthalimide, with CAS No.: 3891-07-4, is the focus of this article, which primarily explores its applications in the field of pharmaceutical intermediates.

I. Cardiovascular Drug Synthesis

NHPI is a key intermediate in the synthesis of Amlodipine Besylate. Amlodipine, a dihydropyridine calcium antagonist, is used for the treatment of hypertension and angina pectoris.

• Synthesis Process: NHPI reacts with 4-chloroacetoacetate ethyl ester and sodium para-toluenesulfonate to produce an intermediate for Amlodipine.

• Advantages: The use of NHPI as an intermediate enhances the efficiency and selectivity of the reaction while reducing the occurrence of side reactions.

II. Antibacterial Drug Synthesis

NHPI is an important raw material for the synthesis of Ceftaroline. Ceftaroline, a broad-spectrum quinolone antibacterial drug, is utilized to treat various bacterial infections.

• Synthesis Process: NHPI reacts with hydrobromic acid to form N-(2-bromoethyl)phthalimide, which is then further reacted to synthesize Ceftaroline.

• Advantages: The introduction of NHPI can enhance the antibacterial activity of the drug, as well as improve its stability and bioavailability.

III. Antiparasitic Drug Synthesis

NHPI is used in the synthesis of Furanodiamine, a drug for the treatment of schistosomiasis.

• Synthesis Process: NHPI acts as an intermediate in the synthesis of Furanodiamine, generating the target compound through a series of chemical reactions.

• Advantages: The use of NHPI can increase the efficiency of synthesis while reducing production costs.

IV. Synthesis of Other Drugs

• Anticancer Drugs: NHPI can be used to prepare compounds such as 4H-pyran-4-carbaldehyde oxime, RNA peptide conjugates, and glycopeptide cephalosporins, which have significant applications in anticancer drugs.

• Antiviral Drugs: NHPI can be used to produce Amikacin, an antibiotic for the treatment of severe bacterial infections.

• Diabetes Drugs: NHPI can also be used to synthesize certain diabetes medications by regulating the metabolic processes of the drugs to enhance their efficacy.

V. Advantages as a Synthetic Intermediate

• High Reactivity: The hydroxyl and phthalimide groups of NHPI exhibit high reactivity, enabling participation in various chemical reactions such as substitution, addition, and redox reactions.

• Good Selectivity: NHPI demonstrates good selectivity in reactions, which can increase the yield and purity of the target product.

• Green Synthesis: NHPI, acting as an oxidation catalyst, can replace traditional heavy metal oxidizing agents to achieve green chemical synthesis.

VI. Summary of Application Cases

• Amlodipine Besylate: NHPI serves as a key intermediate in the synthesis of the antihypertensive drug Amlodipine.

• Ceftaroline: NHPI is used in the synthesis of the broad-spectrum antibacterial drug Ceftaroline.• Furanodiamine: NHPI is used in the synthesis of Furanodiamine, a drug for the treatment of schistosomiasis.

• Anticancer and Antiviral Drugs: NHPI is used in the synthesis of various intermediates for anticancer and antiviral drugs.

VII. Introduction to Xi'an Veda Chemical Co., Ltd.

Xi'an Veda Chemical Co., Ltd. is professionally committed to providing high-quality N-Hydroxyethylphthalimide (NHPI) and has significant advantages in NHPI production:

1. Superior Product Quality: The company strictly controls the production process to ensure that NHPI meets high standards. It also offers customized production according to clients' specific needs to satisfy diverse requirements.

2. Adequate Inventory: The company maintains a substantial inventory of NHPI products, enabling it to meet urgent procurement demands from clients of various sizes without disrupting their production plans.

3. Rapid After-Sales Response Service: With a comprehensive after-sales service system, the company can quickly respond to clients' issues and needs, providing timely technical support and solutions to ensure client satisfaction.

Xi'an Veda Chemical Co., Ltd. warmly welcomes industry friends to consult and explore cooperation opportunities, working together to advance the development of the pharmaceutical intermediate industry.