Ethyl 3-Aminocrotonate (CAS 626-34-6/7318-00-5) - A Versatile Chemical Intermediate​

Ethyl 3-aminocrotonate (C₆H₁₁NO₂) is a significant organic intermediate that appears as a colorless to pale yellow transparent liquid (solid in winter). With broad industrial applications, it serves as a key raw material in pharmaceutical, agrochemical, and fine chemical industries.

​1. Ethyl 3-aminocrotonate in Pharmaceutical Applications​

1. ​Antibiotic Synthesis​
   As a crucial intermediate for β-lactam antibiotics:

   • Cephalosporins: Key material for cefalexin, cephradine, etc.
   • Penicillin derivatives: Used in specialized penicillin production
   • Carbapenems: Essential for imipenem, meropenem synthesis

2. ​Anticancer Drug Development​

   • Precursor for pyrimidine-based antitumor agents
   • Active fragment in targeted therapy drugs
   • Intermediate for antimetabolite anticancer medications

3. ​Cardiovascular Drugs​

   • Used in calcium channel blocker synthesis
   • Intermediate for antihypertensives and antiarrhythmics
   • Component in microcirculation-improving formulations

4. ​Neurological Medications​

   • Building block for antiepileptic drugs
   • Intermediate in antidepressant synthesis
   • Used in neuroprotective compound preparation

​2. Ethyl 3-aminocrotonate in Agrochemical Applications​

1. ​Insecticide Production​

   • Key intermediate for neonicotinoid insecticides
   • Used in synthetic pyrethroid manufacturing
   • Component in specialized insecticidal formulations

2. ​Fungicide Development​

   • Intermediate for triazole/imidazole fungicides
   • Raw material for agricultural antibiotics
   • Used in plant disease control agents

3. ​Herbicide Formulations​

   • Key material for sulfonylurea herbicides
   • Intermediate for selective herbicides
   • Component in eco-friendly weed control solutions

3. Ethyl 3-aminocrotonate in Fine Chemical Applications​

1. ​Dye & Pigment Industry​

   • Intermediate for specialty azo dyes
   • Building block for fluorescent/functional dyes
   • Used in high-performance organic pigments

2. ​Fragrance Manufacturing​

   • Intermediate for fruity-flavored compounds
   • Key material for premium perfume ingredients
   • Used in specialty aroma chemicals

3. ​Functional Materials​

   • Intermediate for liquid crystal materials
   • Raw material for optoelectronic components
   • Used in specialty polymer modification

​4. Ethyl 3-aminocrotonate in Research Applications​

1. ​Organic Synthesis​

   • Michael acceptor in key reactions
   • Building block for N-heterocycles
   • Used in complex molecular synthesis

2. ​Drug Discovery​

   • Key intermediate in drug screening
   • Used in compound library construction
   • Essential for molecular modification

3. ​Biochemical Research​

   • Probe for enzymatic reaction studies
   • Precursor for biomarker synthesis
   • Used in bioactive molecule optimization

​5. Ethyl 3-aminocrotonate in Specialty Applications​

1. Electronic chemicals: Intermediate for high-purity reagents