1. Basic Information

• Chinese Name: 2‑Chlorotrityl Alcohol Resin (2‑CTA Resin)
• English Name: 2‑Chlorotrityl Alcohol Resin, 2‑CTA Resin
• CAS No.: 934816‑82‑7
• Solid Support: Polystyrene beads cross‑linked with 1% or 2% divinylbenzene (DVB)

2. Appearance & Typical Specifications

• Physical State: Off‑white to pale beige insoluble resin microspheres
• Mesh Size: Common grades: 100‑200 mesh, 200‑400 mesh
• Hydroxyl Loading Capacity: Commercial range 0.4～1.8 mmol/g, popular grades: 0.8‑1.2 mmol/g, 1.0‑1.5 mmol/g
• Swelling Behavior: Good swelling in DCM, DMF and NMP (3‑9 mL/g), consistent with 2‑CTC resin.

3. Key Chemical Properties

1. The tertiary hydroxyl group cannot directly load Fmoc‑amino acids. Chlorination (e.g. thionyl chloride) is required to convert ‑OH into reactive ‑Cl to produce 2‑CTC active resin for peptide synthesis.
2. Higher chemical stability than 2‑CTC chloride resin; insensitive to trace moisture during storage.
3. Bulky ortho‑chloro trityl scaffold retains the structural advantage to suppress diketopiperazine (DKP) side‑reactions and amino acid racemization in the final activated resin.
4. Versatile intermediate for further linker modification and custom solid‑phase support development.

4. Main Applications

1. Industrial precursor material for manufacturing 2‑Chlorotrityl Chloride Resin (2‑CTC Resin) for solid‑phase peptide synthesis.
2. Raw material for custom modification of acid‑labile solid supports and novel trityl‑type linkers.
3. Synthetic methodology research and process optimization for peptide resin production.

5. Storage & Handling

• Storage: Keep tightly sealed, dry and protected from light at 2‑8 °C. More stable against moisture compared with 2‑CTC resin.
• Activation Protocol: Chlorination with thionyl chloride (SOCl₂) in DCM is the standard process to obtain active 2‑CTC resin.
• Handle in a fume hood; avoid inhalation of fine resin dust. Waste containing corrosive chlorination reagents must be disposed of in accordance with local environmental regulations.

6. Safety Overview